Hannah Poisner headshot

Hannah M. Poisner

Translating genetics to insights through large-scale computational analysis

PhD Candidate • Computational Genomics

About Me

Bridging computational innovation with production-ready genomic solutions

I'm a PhD candidate in Human Genetics at Vanderbilt University, specializing in large-scale computational genomics and cloud infrastructure. My work focuses on understanding the genetic architecture of immune cell variation across diverse populations.


With experience spanning clinical diagnostics at the New York Genome Center and research at leading academic institutions, I bridge CLIA-certified clinical workflows with cutting-edge research methodologies. I've developed and deployed production-grade pipelines that have processed over 1 million whole genome sequences across major biobanks including All of Us, UK Biobank, and TOPMed.


My approach combines rigorous statistical genetics with scalable cloud computing, enabling discoveries that translate to real-world health impacts. As a first-author in Nature Communications and contributor to multiple high-impact studies, I'm driven by the potential of genomics to transform our understanding of human health and disease.

1.1M+
WGS Samples Processed
3
Major Biobanks
CLIA
Certified Experience

Experience

From clinical diagnostics to research innovation

Vanderbilt University
Graduate Research AssistantBick and Cox Labs
Nov 2021 - Present
  • Architected cloud-native pipelines processing 1M+ genomes across All of Us, UK Biobank, and TOPMed
  • Built production-ready genetic association testing infrastructure for 1.1M+ WGS samples
  • Led multi-ancestry GWAS studies identifying genetic determinants of immune cell fractions
  • Developed single-cell DNA somatic variant analysis framework applied to 1,000+ cells
  • Mentored laboratory members on cloud computing and facilitated Terra/All of Us onboarding
WDLGCPDNANexusREGENIEPythonR
New York Genome Center
Bioinformatics Analyst, Molecular DiagnosticsClinical Laboratory
Jul 2018 - Jul 2021
  • Engineered production pipelines for clinical WGS with CLIA certification
  • Led validation of NovaSeq workflow transition with comprehensive benchmarking
  • Developed custom tools streamlining variant curation for medical directors
  • Maintained compliance with New York State regulatory standards
GCPGATKMantaCanvasPythonBash
Icahn School of Medicine at Mount Sinai
Graduate Research AssistantKenny Lab
Oct 2016 - Jun 2018
  • Developed comprehensive IBD analysis software for diverse populations
  • Conducted GWAS of height in Latino populations for HCHS/SOL consortium
  • Analyzed population structure in UK Biobank cohort
PythonRPLINK

Technical Expertise

Breadth and depth across genomics, stats, and infrastructure

Genomic Analysis
GATKPLINKBCFtools/SAMtoolsREGENIEVariant Calling
Statistical Genetics
GWASRare Variant AnalysisPolygenic Risk ScoresMendelian Randomization
Cloud & Infrastructure
GCP (Terra, All of Us)AWS (DNANexus)HPC (SLURM, SGE)Docker
Programming
PythonRWDLBashSQL

Research & Publications

Selected works and manuscripts

Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals
Poisner, H., Faucon, A., Cox, N., et al.Nature Communications (2024)

Identified genetic variants influencing immune cell composition across diverse populations, with implications for autoimmune disease and infection susceptibility.

DOI: 10.1038/s41467-024-51095-1
Variance quantitative trait loci reveal gene-gene interactions which alter blood traits
Pershad, Y*., Poisner, H*., Corty, R.W., Hellwege, J.N., Bick, A.G.medRxiv (2024)

Education

Doctor of PhilosophyHuman Genetics
Vanderbilt UniversityNashville, TNExpected Jan 2026
  • Advisors: Alexander G. Bick, MD, PhD and Nancy J. Cox, PhD
  • Focus: Population genomics, immune genetics, cloud-scale computational infrastructure
Master of ScienceBiomedical Informatics
Icahn School of Medicine at Mount SinaiNew York, NY2018
Bachelor of ArtsGenetics, Evolutionary Anthropology
Rutgers UniversityNew Brunswick, NJ2016

Get in touch

Open to roles in biotech, pharma, and research